edugeneedugene2013
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  • Institution/s: Rheinische Friedrich-Wilhelms-Universität Bonn, Universidad de Alicante, Universidad de Valladolid, Université d'Artois
  • Project: Diccionario Terminológico de Genética (Eurogene)
  • Identification number: 155
  • Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
  • Author/s: Beatriz BURGOS CUADRILLERO, Marie-Hélène GARCIA, Sara LOZANO DIONISIO, Teresa AMIDO LOZANO
  • Creation / modification date: 27-02-2014
  • Term: metaphase
  • Gramatical category: s
  • Definition: Metaphase is a stage during the process of cell division (mitosis or meiosis). Usually, individual chromosomes cannot be observed in the cell nucleus. However, during metaphase of mitosis or meiosis the chromosomes condense and become distinguishable as they align in the center of the dividing cell. Metaphase chromosomes are used during the karyotyping procedure that is used to look for chromosomal abnormalities.
  • Context: A particularly high risk for early treatment failure and short survival has been associated with CA 13, whether detected by traditional metaphase karyotype analysis (present in 15% of patients)1-4 6 or, more recently, by interphase fluorescence in situ hybridization (FISH) (present in 50%).
  • Expression: Pretreating cells with ATM kinase inhibitors does not abrogate the metaphase delay.
  • Weighting mark: nor
  • Sources:
    • Term: EMERY, A.E.H. y MUELLER, R.F. (1992) Elements of Medical Genetics, Churchill Livingstone: New York. 8th Edition.
    • Definition: GENETICS HOME REFERENCE (2013) „Metaphase“. Recuperado el 23 de diciembre de 2013 de: http://ghr.nlm.nih.gov/glossary=metaphase
    • Context: SHAUGHNESSY, J. (2003) „Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global
    • Expression: MIKHAILOV, A. (2002) „DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint“. Current Biology, Cambridge. Recuperado el 23 de diciembre de 2013 de:http://www.ncbi.nlm.nih.gov/pubmed/12419
  • Images:
    • metaphase
      http://www.snv.jussieu.fr/bmedia/cyclecellBM/05meta_ana.htm#transition
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