- Institution/s: Rheinische Friedrich-Wilhelms-Universität Bonn, Universidad de Alicante, Universidad de Valladolid, Université d'Artois
- Project: Diccionario Terminológico de Genética (Eurogene)
- Identification number: 155
- Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
- Author/s: Beatriz BURGOS CUADRILLERO, Marie-Hélène GARCIA, Sara LOZANO DIONISIO, Teresa AMIDO LOZANO
- Creation / modification date: 27-02-2014
- Term: metaphase
- Gramatical category: s
- Definition: Metaphase is a stage during the process of cell division (mitosis or meiosis). Usually, individual chromosomes cannot be observed in the cell nucleus. However, during metaphase of mitosis or meiosis the chromosomes condense and become distinguishable as they align in the center of the dividing cell. Metaphase chromosomes are used during the karyotyping procedure that is used to look for chromosomal abnormalities.
- Context: A particularly high risk for early treatment failure and short survival has been associated with CA 13, whether detected by traditional metaphase karyotype analysis (present in 15% of patients)1-4 6 or, more recently, by interphase fluorescence in situ hybridization (FISH) (present in 50%).
- Expression: Pretreating cells with ATM kinase inhibitors does not abrogate the metaphase delay.
- Weighting mark: nor
- Sources:
- Term: WRBA, Fritz, DOLZNIG, Helmut, MANNHALTER, Christine (2011). Genetik verstehen: Grundlagen der molekularen Biologie. 2. Aufl. Wien: Facultas Verlag, 65.
- Definition: WRBA, Fritz, DOLZNIG, Helmut, MANNHALTER, Christine (2011). Genetik verstehen: Grundlagen der molekularen Biologie. 2. Aufl. Wien: Facultas Verlag, 65.
- Context: BUSELMAIER, Werner (2012). Biologie für Mediziner. 12. neubearbeitete und erweiterte Aufl. Berlin, Heidelberg: Springer Verlag, 66.
- Images:
http://www.snv.jussieu.fr/bmedia/cyclecellBM/05meta_ana.htm#transition
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