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  • Institution/s: Universidad de Alicante, Universidad de Saarbrücken, Universidad de Valladolid, Universitatea de Vest din Timişoara
  • Project: Diccionario Terminológico de Genética (Eurogene)
  • Identification number: 74
  • Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
  • Author/s: Andrea COCCARO CASTILLO, Bianca CONSTANTINESCU, Gloria GONZÁLEZ-CALERO, María Eugenia HERRERAS
  • Creation / modification date: 30-01-2014
  • Term: chromatid
  • Gramatical category: s
  • Definition: One of two identical halves of a replicated chromosome. During cell division, the chromosomes first replicate so that each daughter cell receives a complete set of chromosomes. Following DNA replication, the chromosome consists of two identical structures called sister chromatids, which are joined at the centromere.
  • Context: The spindle checkpoint detects improper kinetochore-microtubule attachments and translates these defects into biochemical activities that inhibit the anaphase-promoting complex or cyclosome (APC/C) throughout the cell to delay anaphase onset. A deficient spindle checkpoint leads to premature sister-chromatid separation and aneuploidy.
  • Weighting mark: nor
  • Remission: sin, anomalie génétique . Source: http://www.ac-nancy-metz.fr/enseign/svt/eleve/cyber/Vincent/anogenes.htm .
  • Sources:
    • Term: EMERY, A.E.H. y MUELLER, R.F. (1992) Elements of Medical Genetics, Churchill Livingstone: New York. 8th Edition.
    • Definition: PAVAN, W. Available on the website of the National Human Genome Research Institute. http://www.genome.gov/glossary/index.cfm?id=31
    • Context: JIA L, KIM S, YU H (2013) "Tracking spindle checkpoint signals from kinetochores to APC/C". Trends Biochem Sci. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/23598156
  • Images:
    • chromatid(s)
      http://svt-barcelo.fr/3emes/aide/chromosomes_chromatides.php
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