- Institution/s: Universidad de Valladolid
- Project: Diccionario Terminológico de Genética (Eurogene)
- Identification number: 101
- Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
- Author/s: Ana MUÑOZ GASCÓN, Augustine Edith EMENE, Susana ALVAREZ ALVAREZ
- Creation / modification date: 04-02-2014
- Term: DNA polymerase
- Gramatical category: s
- Definition: An enzyme that catalyzes (speeds) the polymerization of DNA. DNA polymerase uses preexisting nucleic acid templates and assembles the DNA from deoxyribonucleotides; it is necessary for the incorporation of precursor substances into new DNA.
- Context: In the yeast Saccharomyces cerevisiae, reduced levels of the replicative α DNA polymerase result in greatly elevated frequencies of chromosome translocations and chromosome loss. We selected translocations in a small region of chromosome III and found that they involve homologous recombination events between yeast retrotransposons (Ty elements) on chromosome III and retrotransposons located on other chromosomes.
- Weighting mark: nor
- Sources:
- Term: EMERY, A.E.H. Y MUELLER, R.F. (1992) Elements of Medical Genetics, Churchill Livingstone: New York. 8th Edition. (p. 159)
- Definition: http://www.medterms.com/script/main/art.asp?articlekey=3094 ; EMERY, A.E.H. Y MUELLER, R.F. (1992) Elements of Medical Genetics, Churchill Livingstone: New York. 8th Edition. (p. 159)
- Context: LEMOINE, F.J. , DEGTYAREVA, N.P. et al. (2005) “Chromosomal Translocations in Yeast Induced by Low Levels of DNA Polymerase: A Model for Chromosome Fragile Sites”, CELL, 120 (5) : p. 587.
- Images:
http://es.wikipedia.org/wiki/ADN_polimerasa
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