Project: Diccionario Terminológico de Genética (Eurogene)
Identification number: 21
Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
Author/s: Marta VALDENEBRO ARENAS, Patricia ROJO DE DOMINGO, Regina CAVA GARCÍA, Rubén ORTIZ PAMPLIN
Creation / modification date: 01-03-2014
Term: proto-oncogene(s)
Gramatical category: s
Definition: A gene having the potential for change into an active oncogene.
Context: We hypothesized that 3'UTR SNPs in miRNA binding sites of proto-oncogenes could abrogate their post-transcriptional regulation, resulting in overexpression of oncogenic proteins, tumor initiation, progression, and modulation of drug response in cancer patients.
Expression: Proto-oncogene is activated
Activated proto-oncogene