- Institution/s: Universidad de Alicante, Universidad de Valladolid, Universitatea de Vest din Timişoara
- Project: Diccionario Terminológico de Genética (Eurogene)
- Identification number: 76
- Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
- Author/s: Aida GONZÁLEZ ALBORS, Bianca CONSTANTINESCU, María Eugenia HERRERAS , Marta VALDENEBRO ARENAS
- Creation / modification date: 30-01-2014
- Term: chromosome instability
- Gramatical category: s
- Definition: Increased rate of chromosome missegregation in mitosis resulting in a failure to maintain the correct chromosomal complement (euploidy).
- Context: Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity.
- Weighting mark: nor
- Remission: hipo, trisomie 13 ou syndrome de Patau . Source: http://www.chambon.ac-versailles.fr/science/sante/genet/anomchrom.htm.
- Sources:
- Term: EMERY, A.E.H. y MUELLER, R.F. (1992) Elements of Medical Genetics, Churchill Livingstone: New York. 8th Edition.
- Definition: YUEN K, WING Y (Oct 2010) “Chromosome Instability (CIN), Aneuploidy and Cancer”. In: eLS. John Wiley & Sons Ltd, Chichester. Recuperado el 25 de abril de 2013 de: http://www.els.net/WileyCDA/ElsArticle/refId-a0022413.html
- Context: NOWAK A, KOMAROVA N, et al. (2002) “The role of chromosomal instability in tumor initiation” PNAS 2002 99 (25) 16226-16231; published ahead of print November 21, 2002, doi:10.1073/pnas.202617399 Recuperado el 25 de abril de 2013 de: http://www.pnas.org/content/99/25/16226.full.pdf+html
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