- Institution/s: Universidad de Alicante, Universidad de Valladolid, Universitatea de Vest din Timişoara
- Project: Diccionario Terminológico de Genética (Eurogene)
- Identification number: 76
- Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
- Author/s: Aida GONZÁLEZ ALBORS, Bianca CONSTANTINESCU, María Eugenia HERRERAS , Marta VALDENEBRO ARENAS
- Creation / modification date: 30-01-2014
- Term: chromosome instability
- Gramatical category: s
- Definition: Increased rate of chromosome missegregation in mitosis resulting in a failure to maintain the correct chromosomal complement (euploidy).
- Context: Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity.
- Weighting mark: nor
- Remission: hipo, trisomie 13 ou syndrome de Patau . Source: http://www.chambon.ac-versailles.fr/science/sante/genet/anomchrom.htm.
- Sources:
- Term: BUSELMAIER, Werner (2012). Biologie für Mediziner. 12. neubearbeitete und erweiterte Aufl. Berlin, Heidelberg: Springer Verlag, 136.
- Definition: Seyffert, Wilhelm (2003) Lehrbuch der Genetik 2. Auflage, Spektrum Akademischer Verlag Heidelberg, 694f.
- Context: BUSELMAIER, Werner (2012). Biologie für Mediziner. 12. neubearbeitete und erweiterte Aufl. Berlin, Heidelberg: Springer Verlag, 147.
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