- Institution/s: Rheinische Friedrich-Wilhelms-Universität Bonn, Universidad de Alicante, Universidad de Valladolid, Université d'Artois
- Project: Diccionario Terminológico de Genética (Eurogene)
- Identification number: 181
- Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
- Author/s: Beatriz BURGOS CUADRILLERO, Gema GUNTIÑAS FRAU, Isaac MORENO RUIZ, Marie-Hélène GARCIA
- Creation / modification date: 27-02-2014
- Term: non disjunction
- Gramatical category: s
- Definition: The failure of paired chromosomes or sister chromatids to separate and go to different cells during meiosis.
- Context: Over 300 cases of trisomy 21 were analyzed to characterize the causes of maternal non-disjunction and to evaluate the basis for maternal age-dependent trisomy 21. We confirmed the observation that recombination along 21q is reduced among non-disjoined chromosomes 21 and further demonstrated that the alterations in recombination are restricted to meiosis I origin.
- Weighting mark: nor
- Sources:
- Term: EMERY, A. (2009), Elementos de genética médica. Barcelona: Ed. Elsevier, 13ª Edición. (Revisión científica a cargo del Dr. Rafael Oliva Virgili).
- Definition: Recursos de biología y geología. (2007). Alteraciones de la información genética. Recuperado el 11 de noviembre de 2013, de http://www.bioygeo.info/pdf/16_Mutaciones.pdf. LACADENA, J.R. (1996). Citogenética. Madrid: Editorial Complutense.
- Context: LACADENA, J.R. (1996). Citogenética. Madrid: Editorial Complutense.
- Notes: LACADENA, J.R. (1996). Citogenética. Madrid: Editorial Complutense.
- Images:
http://zytogenetikforum.at/html/index.php/basiswissen/128-crossingover (abgerufen im November 2013).
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