- Institution/s: Rheinische Friedrich-Wilhelms-Universität Bonn, Universidad de Alicante, Universidad de Valladolid, Université d'Artois
- Project: Diccionario Terminológico de Genética (Eurogene)
- Identification number: 181
- Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
- Author/s: Beatriz BURGOS CUADRILLERO, Gema GUNTIÑAS FRAU, Isaac MORENO RUIZ, Marie-Hélène GARCIA
- Creation / modification date: 27-02-2014
- Term: non disjunction
- Gramatical category: s
- Definition: The failure of paired chromosomes or sister chromatids to separate and go to different cells during meiosis.
- Context: Over 300 cases of trisomy 21 were analyzed to characterize the causes of maternal non-disjunction and to evaluate the basis for maternal age-dependent trisomy 21. We confirmed the observation that recombination along 21q is reduced among non-disjoined chromosomes 21 and further demonstrated that the alterations in recombination are restricted to meiosis I origin.
- Weighting mark: nor
- Sources:
- Term: EMERY, A.E.H. y MUELLER, R.F. (1992) Elements of Medical Genetics, Churchill Livingstone: New York. 8th Edition.
- Definition: The American Heritage Science Dictionary. (2005). Consultado el 28 de enero de 2014
- Context: SHERMAN, S.L. et al. (1994) “Non-disjunction of chromosome 21 in maternal meiosis I: evidence for a maternal age-dependent mechanism involving reduced recombination”. Human Molecular Genetics, 3 (9), p. 1529.
- Images:
http://zytogenetikforum.at/html/index.php/basiswissen/128-crossingover (abgerufen im November 2013).
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