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  • Institution/s: Universidad de Alicante, Universidad de Valladolid, Universitatea de Vest din Timişoara
  • Project: Diccionario Terminológico de Genética (Eurogene)
  • Identification number: 103
  • Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
  • Author/s: Andrés DE PEDRO SCHMIDT, Diana MOŢOC, Marco GARCÍA SPATA, Marta VALDENEBRO ARENAS, Verónica ARNÁIZ UZQUIZA
  • Creation / modification date: 01-02-2014
  • Term: restriction enzymes
  • Gramatical category: s
  • Definition: Enzymes isolated from bacteria that recognize specific sequences in DNA and then cut the DNA to produce fragments, called restriction fragments.
  • Context: A difference in the nucleotide sequence of the sixth codon of the beta-globin gene between HbA and HbS, resulting in the substitution of valine for glutamic acid along with the recognition site nucleotide sequence of the restriction enzyme Mst II, produces a 1.3kb restriction fragment with a probe to the 5’ end of the beta-globin gene in DNA from persons with the sickle-cell gene rather than a 1.1 Kb fragment with DNA from the normal beta-globin gene.
  • Remission: sin, X-inactivation Fuente: U.S. National Library of Medicine, Genetics Home Reference. May 13, 2013. [Online], Available on: http://ghr.nlm.nih.gov/glossary=xchromosomeinactivation, [Date consulted] 11/05/13
  • Sources:
    • Term: SCHAAF, Christian, ZSCHOCKE, Johannes (2013). Basiswissen Humangenetik. 2. Aufl. Berlin, Heidelberg: Springer Verlag, 150.
    • Definition: SCHAAF, Christian, ZSCHOCKE, Johannes (2013). Basiswissen Humangenetik. 2. Aufl. Berlin, Heidelberg: Springer Verlag, 150.
    • Context: BUSELMAIER, Werner (2012). Biologie für Mediziner. 12. neubearbeitete und erweiterte Aufl. Berlin, Heidelberg: Springer Verlag, 208.
  • Images:
    • restriction enzyme
      http://bsp.med.harvard.edu/node/41
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