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  • Institution/s: Universidad de Saarbrücken, Universidad de Valladolid, Universitatea de Vest din Timişoara
  • Project: Diccionario Terminológico de Genética (Eurogene)
  • Identification number: 54
  • Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
  • Author/s: Judith CARRERA FERNÁNDEZ, Laura SANJUÁN LANCHO, Raluca RADAC, Rosario HERRERO
  • Creation / modification date: 01-03-2014
  • Term: heterochromatin
  • Gramatical category: s
  • Definition: Chromatin of specific parts of certain chromosomes which remains condensed throughout interphase whilst retaining the deeply staining properties of metaphase chromosomes, but also a pattern of DNA replication out of phase with that of remaining euchromatic parts of the chromosomes, and a relative transcriptional inactivity.
  • Context: We propose that perpetuation of heterochromatin involves self-maintenance factors, including local concentration of Hp1α and -β, and that a degree of plasticity is provided by the cycle of H4 acetylation/deacetylation assisted by CAF-1.
  • Expression: (1) Heterochromatin protein HP1 (2) Constitutive heterochromatin (3) Facultative heterochromatin
  • Weighting mark: nor
  • Remission: sin, ley de Hardy-Weinberg/equilibrio de Hardy-Weinberg Fuente: BENITO, J. C. y N. F. J. ESPINO (2012). “Glosario”, en Genética: Conceptos esenciales. Madrid [etc: Médica Panamericana. OLIVA, R. (2002). Genética médica. Barcelona: Edicions Universitat de Barcelona.
  • Sources:
    • Term: EMERY, A.E.H. y MUELLER, R.F. (1992) Elements of Medical Genetics, Churchill Livingstone: New York. 8th Edition.
    • Definition: MELLO, M. L. S. (1983). Cytochemical properties of euchromatin and heterochromatin. The Histochemical Journal, 15, 739. Recuperado el 25 de abril de 2013 de: http://link.springer.com/article/10.1007/BF01003338#page-1
    • Context: TADDEI, A., ROCHE, D., SIBARITA, J. B., TURNER, B.M. y G. ALMOUZNI (1999). Duplication and maintenance of heterochromatin domains. The Journal of Cell Biology, 147 (6), 1153. Recuperado el 25 de abril de 2013 de: http://jcb.rupress.org/content/147/6/1153.full.pdf+html
    • Expression: (1) GREWAL, S.I.S y S. JIA (2007). Heterochromatin revisited. Nature Reviews Genetic, 8, 35-46. Recuperado el 25 de abril de 2013 de: http://www.columbia.edu/cu/biology/faculty/jia/1.pdf (2) DILLON, N. (2004). Heterochromatin structure and function. Londres: Biology of the Cell, 96 (8), 631-637. Recuperado el 25 de abril de 2013 de: http://www.biolcellusa.org/boc/096/0631/boc0960631.pdf (3) (2) DILLON, N. (2004). Heterochromatin structure and function. Londres: Biology of the Cell, 96 (8), 631-637. Recuperado el 25 de abril de 2013 de: http://www.biolcellusa.org/boc/096/0631/boc0960631.pdf
  • Images:
    • heterochromatin
      http://commons.wikimedia.org/wiki/File:Nucleus_of_a_chloride_cell.jpg
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