Definition: Condition of abnormality involving the chromosomal number resulting from presence (trisomic) or absence (monosomic) of a single extra chromosome in the cells.
Context: CIN (chromosomal instability) is characterized by aneuploidy and loss of heterozygosity (LOH), and leads to losses of tumor suppressor genes on chromosomes 5q, 18q, and 17p.
Notes: aneuploid (n.), aneuploid (adj.)
Weighting mark: nor
Sources:
Term: ABOUELMAGD, A. & H. M. AGEELY (2009) Basic Genetics: Textbook and Activities, Boca Ratón: Universal Publishers. 222
Definition: ABOUELMAGD, A. & H. M. AGEELY (2009) Basic Genetics: Textbook and Activities, Boca Ratón: Universal Publishers. 222
Context: TOLLEFSBOL, T. (2011) Handbook of Epigenetics: The New Molecular and Medical Genetics, London: Elsevier. 487.
Notes: TOLLEFSBOL, T., (2011) Handbook of Epigenetics: The New Molecular and Medical Genetics, London: Elsevier. 487.
Images:
RINGO, J. (2004), Fundamental Genetics, Cambridge: Cambridge University Press. 196