- Institution/s: Universidad de Valladolid
- Project: Diccionario Terminológico de Genética (Eurogene)
- Identification number: 100
- Subdomains: Studies of chromatin, Studies of DNA, Studies of RNA, Techniques
- Author/s: Ana MUÑOZ GASCÓN, Augustine Edith EMENE, Susana ALVAREZ ALVAREZ
- Creation / modification date: 04-02-2014
- Term: DNA ligase
- Gramatical category: s
- Definition: An enzyme that can repair breaks in a strand of deoxyribonucleic acid (DNA) by synthesizing a bond between adjoining nucleotides. Under some circumstances the enzyme can join together loose ends of DNA strands, and in some cases it can repair breaks in ribonucleic acid (RNA). It serves as a catalyst.
- Context: Polymerase chain reaction, using thermostable DNA polymerase, has revolutionized DNA diagnostics. Another thermostable enzyme, DNA ligase, is harnessed in the assay reported here that both amplifies DNA and discriminates a single-base substitution.
- Weighting mark: nor
- Sources:
- Term: François GROS (1982) : Hérédité et manipulations génétiques, Paris.
- Definition: Alphonse MEYER, José DEIANA, Alain BERNARD (2004) : Cours de microbiologie générale : avec problèmes et exercices corrigés, Berlin, p. 48
- Context: Alphonse MEYER, José DEIANA, Alain BERNARD (2004) : Cours de microbiologie générale : avec problèmes et exercices corrigés, Berlin, p. 48
- Images:
http://es.wikipedia.org/wiki/ADN_ligasa
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